Prediction of Glycosyltransferases Synthesizing Glycoconjugates Using Variable-length N-gram Model

Glycoconjugates, products of uridine derivatives phosphitylation and oxidation as glycosyltransferases potential inhibitors.

The title compounds, variously protected 5'-uridine derivatives connected with 1-thiosugar with thio-phosphoesters fragment (17-22) were synthesized in sequence of reactions: phosphitylation--reaction of 5'-hydroxyl group of selectively protected nucleoside with a phosphitylating agent (N,N-diisopropyl chlorophosphoamidite), connection an phosphoroamidites with 2-bromoethanol or 3-bromopropanol...

Glycosyltransferases: cell surface remodeling and regulation of receptor tyrosine kinases-induced signaling*

The biosynthesis and degradation of glycoconjugates are catalyzed by glycosyltransferases and glycosidases, respectively, and the genes which encode glycosyltransferases and related proteins are referred to as `glyco-genes'. The expression of glycosyltransferases, the substrate speci®city of the enzymes and their subcellular localization represent key determinants in the biosynthesis of sugar c...

Two soluble glycosyltransferases glycosylate less efficiently in vivo than their membrane bound counterparts.

Many Golgi glycosyltransferases are type II membrane proteins which are cleaved to produce soluble forms that are released from cells. Cho and Cummings recently reported that a soluble form of alpha1, 3-galactosyltransferase was comparable to its membrane bound counterpart in its ability to galactosylate newly synthesized glycoproteins (Cho,S.K. and Cummings,R.D. (1997) J. Biol. Chem., 272, 136...

Comparative aspects of glycosyltransferases.

Glycosyltransferases, the enzymes that build oligosaccharides and glycoconjugates, have received much interest in recent years owing to their biological functions and their potential uses in biotechnology. Despite the fact that many glycosyltransferases recognize similar donor or acceptor substrates, there is surprisingly limited sequence identity between different classes. On the one hand, the...

N-gram Modeling of Tabla Sequences Using Variable-length Hidden Markov Models for Improvisation and Composition